Response to Hypomethylating Agents in Myelodysplastic Syndrome Is Associated With Emergence of Novel TCR Clonotypes

Response to Hypomethylating Agents in Myelodysplastic Syndrome Is Associated With Emergence of Novel TCR Clonotypes

Aberrant T-cell function is implicated in the pathogenesis of myelodysplastic syndrome (MDS). Monitoring the T-cell receptor (TCR) repertoire can provide insights into T-cell adaptive immunity. Previous studies found skewed TCR repertoires in MDS compared to healthy patients; however these studies t...

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Bibliographic Details
Main Authors: Hussein A. Abbas, Patrick K. Reville, Xianli Jiang, Hui Yang, Alexandre Reuben, Jin Seon Im, Latasha Little, Jefferson C. Sinson, Ken Chen, Andrew Futreal, Guillermo Garcia-Manero
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
myelodysplastic syndrome
T-cell repertoire
diversity
clonality
antigen recognition
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.659625/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.659625/full

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