Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities

Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities

Several genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) have been shown to increase the risk of developing Alzheimer’s disease (AD) supporting a role of microglia and immune cells in the pathobiology of AD. We have employed an ectopic model of TREM2 and DAP12 express...

Full description

Bibliographic Details
Main Authors: Hailan Yao, Kyle Coppola, Jonas Elias Schweig, Fiona Crawford, Michael Mullan, Daniel Paris
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Alzheimer’s disease
TREM2
inflammation
signaling pathways
phagocytosis
SYK
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00457/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00457/full

Similar Items