The case of the fickle fingers: how the PRDM9 zinc finger protein specifies meiotic recombination hotspots in humans.
During mammalian meiosis, double-strand breaks are deliberately made throughout the genome and then repaired, leading to the exchange of genetic material between copies of chromosomes. How the locations of breaks are specified was largely unknown until a fortuitous confluence of statistical genetics...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-12-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC3232208?pdf=render |