Polymyxin B inadequately quenches the effects of contaminating lipopolysaccharide on murine dendritic cells.

Dendritic cell (DC) activation is commonly used as a measure of the immunomodulatory potential of candidate exogenous and endogenous molecules. Residual lipopolysaccharide (LPS) contamination is a recurring theme and the potency of LPS is not always fully appreciated. To address this, polymyxin B (P...

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Bibliographic Details
Main Authors: Graham A Tynan, Anne McNaughton, Andrew Jarnicki, Takao Tsuji, Ed C Lavelle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3356265?pdf=render