Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques

Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques

High frequency semen exposure has been associated with activation of anti-HIV mechanisms in HIV negative sex workers. Here, Abdulhaqq et al. show that repeated vaginal exposure to semen reduces vaginal infection by SIV in non-human primates, and is associated with lower CCR5 expression in CD4 T-cell...

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Bibliographic Details
Main Authors: Shaheed A. Abdulhaqq, Melween Martinez, Guobin Kang, Idia V. Rodriguez, Stephanie M. Nichols, David Beaumont, Jocelin Joseph, Livio Azzoni, Xiangfan Yin, Megan Wise, David Weiner, Qin Liu, Andrea Foulkes, Jan Münch, Frank Kirchhoff, Christos Coutifaris, Georgia D. Tomaras, Carlos Sariol, Preston A. Marx, Qingsheng Li, Edmundo N. Kraiselburd, Luis J. Montaner
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11814-5

Internet

https://doi.org/10.1038/s41467-019-11814-5

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