Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction.

Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction.

Serine-threonine protein kinases are critical to CNS function, yet there is a dearth of highly selective, CNS-active kinase inhibitors for in vivo investigations. Further, prevailing assumptions raise concerns about whether single kinase inhibitors can show in vivo efficacy for CNS pathologies, and...

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Bibliographic Details
Main Authors: D Martin Watterson, Valerie L Grum-Tokars, Saktimayee M Roy, James P Schavocky, Brinda Desai Bradaric, Adam D Bachstetter, Bin Xing, Edgardo Dimayuga, Faisal Saeed, Hong Zhang, Agnieszka Staniszewski, Jeffrey C Pelletier, George Minasov, Wayne F Anderson, Ottavio Arancio, Linda J Van Eldik
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3694096?pdf=render

Internet

http://europepmc.org/articles/PMC3694096?pdf=render

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