Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMT

Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMT

Abstract Background NUDT15 and TPMT variants are strong genetic determinants of thiopurine-induced hematological toxicity that results in therapeutic failure in pediatric acute lymphoblastic leukemia (ALL). However, many patients with both wild-type (WT) NUDT15 and TPMT still suffer from thiopurine...

Full description

Bibliographic Details
Main Authors: Yoomi Park, Hyery Kim, Heewon Seo, Jung Yoon Choi, Youngeun Ma, Sunmin Yun, Byung-Joo Min, Myung-Eui Seo, Keon Hee Yoo, Hyoung Jin Kang, Ho Joon Im, Ju Han Kim
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Translational Medicine
Subjects:
CRIM1
NUDT15
TPMT
6-Mercaptopurine
Toxicity
Acute lymphoblastic leukemia
Online Access:http://link.springer.com/article/10.1186/s12967-020-02416-7

Internet

http://link.springer.com/article/10.1186/s12967-020-02416-7

Similar Items