Early-Life Exposure to Environmental Contaminants Perturbs the Sperm Epigenome and Induces Negative Pregnancy Outcomes for Three Generations via the Paternal Lineage

Early-Life Exposure to Environmental Contaminants Perturbs the Sperm Epigenome and Induces Negative Pregnancy Outcomes for Three Generations via the Paternal Lineage

Due to the grasshopper effect, the Arctic food chain in Canada is contaminated with persistent organic pollutants (POPs) of industrial origin, including polychlorinated biphenyls and organochlorine pesticides. Exposure to POPs may be a contributor to the greater incidence of poor fetal growth, place...

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Bibliographic Details
Main Authors: Clotilde Maurice, Mathieu Dalvai, Romain Lambrot, Astrid Deschênes, Marie-Pier Scott-Boyer, Serge McGraw, Donovan Chan, Nancy Côté, Ayelet Ziv-Gal, Jodi A. Flaws, Arnaud Droit, Jacquetta Trasler, Sarah Kimmins, Janice L. Bailey
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Epigenomes
Subjects:
persistent organic pollutants (POPs)
sperm methylome
intergenerational
transgenerational
epigenetic
paternal transmission
Online Access:https://www.mdpi.com/2075-4655/5/2/10

Internet

https://www.mdpi.com/2075-4655/5/2/10

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