Synthesis and antibacterial activity of some new 4-anilino-5-phenyl-4H-1,2,4-triazole-3-thiol derivatives

Synthesis and antibacterial activity of some new 4-anilino-5-phenyl-4H-1,2,4-triazole-3-thiol derivatives

4-Anilino-5-phenyl-4H-1,2,4-triazole-3-thiol (1) reacted with formaldehyde and different amines to give Mannich bases 2a–i. Treatment of compound 1 with formaldehyde afforded the corresponding 2-hydroxymethyl derivative 3, which upon its reaction with thionyl chloride yielded the corresponding chlor...

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Bibliographic Details
Main Authors: Abd El-Badih A.G. Ghattas, Hassan M. Moustafa, Elsayed A.A. Hassanein, Bahgat R.M. Hussein
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Arabian Journal of Chemistry
Subjects:
4-Anilino-5-phenyl-4H-1,2,4-triazole-3-thiol
Mannich bases
Triazolotriazoles
Oxadiazolotriazoles
Triazinotriazoles
Antibacterial activity
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535212000846

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http://www.sciencedirect.com/science/article/pii/S1878535212000846

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