Methyl Ferulic Acid Attenuates Human Cardiac Fibroblasts Differentiation and Myocardial Fibrosis by Suppressing pRB-E2F1/CCNE2 and RhoA/ROCK2 Pathway

Methyl Ferulic Acid Attenuates Human Cardiac Fibroblasts Differentiation and Myocardial Fibrosis by Suppressing pRB-E2F1/CCNE2 and RhoA/ROCK2 Pathway

Background: Myocardial fibrosis is a key pathological process after myocardial infarction, which leads to poor outcomes in patients at the end stage. Effective treatments for improving prognosis of myocardial fibrosis are needed to be further developed. Methyl ferulic acid (MFA), a biologically acti...

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Bibliographic Details
Main Authors: Rongheng Liao, Zhen Qi, Ri Tang, Renrong Wang, Yongyi Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
myocardial infarction
methyl ferulic acid
cardiac fibrosis
TGF-β1
E2F1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.714390/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.714390/full

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