Metformin Preconditioning and Postconditioning to Reduce Ischemia Reperfusion Injury in an Isolated Ex Vivo Rat and Porcine Kidney Normothermic Machine Perfusion Model

Metformin Preconditioning and Postconditioning to Reduce Ischemia Reperfusion Injury in an Isolated Ex Vivo Rat and Porcine Kidney Normothermic Machine Perfusion Model

Metformin may act renoprotective prior to kidney transplantation by reducing ischemia‐reperfusion injury (IRI). This study examined whether metformin preconditioning and postconditioning during ex vivo normothermic machine perfusion (NMP) of rat and porcine kidneys affect IRI. In the rat study, sali...

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Bibliographic Details
Main Authors: Tobias M. Huijink, Leonie H. Venema, Rene A. Posma, Nynke J. deVries, Andrie C. Westerkamp, Petra J. Ottens, Daan J. Touw, Maarten W. Nijsten, Henri G.D. Leuvenink
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.12846

Internet

https://doi.org/10.1111/cts.12846

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