Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model

Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model

The ovine critical-sized defect model provides a robust preclinical model for testing tissue-engineered constructs for use in the treatment of non-union bone fractures and severe trauma. A critical question in cell-based therapies is understanding the optimal therapeutic cell dose. Key to defining t...

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Bibliographic Details
Main Authors: Hareklea Markides, Nicola C. Foster, Jane S. McLaren, Timothy Hopkins, Cameron Black, Richard O. C. Oreffo, Brigitte E. Scammell, Iria Echevarria, Lisa J. White, Alicia J. El Haj
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cells
Subjects:
preclinical ovine models
cell viability
magnetic nanoparticles
bone repair
mesenchymal stromal cells
osteogenesis
Online Access:https://www.mdpi.com/2073-4409/10/7/1776

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https://www.mdpi.com/2073-4409/10/7/1776

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