Disruption of myelin leads to ectopic expression of K(V)1.1 channels with abnormal conductivity of optic nerve axons in a cuprizone-induced model of demyelination.

Disruption of myelin leads to ectopic expression of K(V)1.1 channels with abnormal conductivity of optic nerve axons in a cuprizone-induced model of demyelination.

The molecular determinants of abnormal propagation of action potentials along axons and ectopic conductance in demyelinating diseases of the central nervous system, like multiple sclerosis (MS), are poorly defined. Widespread interruption of myelin occurs in several mouse models of demyelination, re...

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Bibliographic Details
Main Authors: Bandita Bagchi, Ahmed Al-Sabi, Seshu Kaza, Dimitri Scholz, Valerie B O'Leary, J Oliver Dolly, Saak V Ovsepian
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3912067?pdf=render

Internet

http://europepmc.org/articles/PMC3912067?pdf=render

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