In Vivo Lentiviral Gene Delivery of HLA-DR and Vaccination of Humanized Mice for Improving the Human T and B Cell Immune Reconstitution

In Vivo Lentiviral Gene Delivery of HLA-DR and Vaccination of Humanized Mice for Improving the Human T and B Cell Immune Reconstitution

Humanized mouse models generated with human hematopoietic stem cells (HSCs) and reconstituting the human immune system (HIS-mice) are invigorating preclinical testing of vaccines and immunotherapies. We have recently shown that human engineered dendritic cells boosted <i>bonafide</i> hum...

Full description

Bibliographic Details
Main Authors: Suresh Kumar, Johannes Koenig, Andreas Schneider, Fredrik Wermeling, Sanjaykumar Boddul, Sebastian J. Theobald, Miriam Vollmer, Doreen Kloos, Nico Lachmann, Frank Klawonn, Stefan Lienenklaus, Steven R. Talbot, André Bleich, Nadine Wenzel, Constantin von Kaisenberg, James Keck, Renata Stripecke
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Biomedicines
Subjects:
humanized mice
stem cell transplantation
HLA match
lentiviral vector
vaccine
B cell maturation
Online Access:https://www.mdpi.com/2227-9059/9/8/961

Internet

https://www.mdpi.com/2227-9059/9/8/961

Similar Items