Lipid Peroxidative Damage on Cisplatin Exposure and Alterations in Antioxidant Defense System in Rat Kidneys: A Possible Protective Effect of Selenium

Lipid Peroxidative Damage on Cisplatin Exposure and Alterations in Antioxidant Defense System in Rat Kidneys: A Possible Protective Effect of Selenium

Cisplatin (Cis-diamminedichloroplatinum II, CP) is an important chemotherapeutic agent, useful in the treatment of several cancers, but with several side effects such as nephrotoxicity. The present study investigated the possible protective effect of selenium (Se) against CP-induced oxidative stress...

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Bibliographic Details
Main Authors: Branka I. Ognjanović, Nataša Z. Djordjević, Andraš Š. Štajn, Jelena M. Mladenović, Jasmina M. Obradović, Zorica S. Saičić, Miloš M. Matić
Format: Article
Language:English
Published: MDPI AG 2012-02-01
Series:International Journal of Molecular Sciences
Subjects:
cisplatin
selenium
nephrotoxicity
lipid peroxidation
antioxidant defense system
Online Access:http://www.mdpi.com/1422-0067/13/2/1790/

Internet

http://www.mdpi.com/1422-0067/13/2/1790/

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