CXCR4/CXCL12 participate in extravasation of metastasizing breast cancer cells within the liver in a rat model.

CXCR4/CXCL12 participate in extravasation of metastasizing breast cancer cells within the liver in a rat model.

INTRODUCTION: Organ-specific composition of extracellular matrix proteins (ECM) is a determinant of metastatic host organ involvement. The chemokine CXCL12 and its receptor CXCR4 play important roles in the colonization of human breast cancer cells to their metastatic target organs. In this study, w...

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Bibliographic Details
Main Authors: Claudia Wendel, André Hemping-Bovenkerk, Julia Krasnyanska, Sören Torge Mees, Marina Kochetkova, Sandra Stoeppeler, Jörg Haier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3258260?pdf=render

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http://europepmc.org/articles/PMC3258260?pdf=render

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