Development of LT-HSC-Reconstituted Non-Irradiated NBSGW Mice for the Study of Human Hematopoiesis In Vivo

Development of LT-HSC-Reconstituted Non-Irradiated NBSGW Mice for the Study of Human Hematopoiesis In Vivo

Humanized immune system (HIS) mouse models are useful tools for the in vivo investigation of human hematopoiesis. However, the majority of HIS models currently in use are biased towards lymphocyte development and fail to support long-term multilineage leucocytes and erythrocytes. Those that achieve...

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Bibliographic Details
Main Authors: George Adigbli, Peng Hua, Masateru Uchiyama, Irene Roberts, Joanna Hester, Suzanne M. Watt, Fadi Issa
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
human immune system mice
human hematological reconstitution in vivo
immune reconstitution
red blood cell reconstitution
non-irradiation
genome editing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.642198/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.642198/full

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