Molecular Signatures of the Insulin-Like Growth Factor 1-Mediated Epithelial-Mesenchymal Transition in Breast, Lung and Gastric Cancers

Molecular Signatures of the Insulin-Like Growth Factor 1-Mediated Epithelial-Mesenchymal Transition in Breast, Lung and Gastric Cancers

The insulin-like growth factor (IGF) system, which is constituted by the IGF-1 and IGF-2 peptide hormones, their corresponding receptors and several IGF binding proteins, is involved in physiological and pathophysiological processes. The IGF system promotes cancer proliferation/survival and its sign...

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Bibliographic Details
Main Authors: Armando Cevenini, Stefania Orrù, Annamaria Mancini, Andreina Alfieri, Pasqualina Buono, Esther Imperlini
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
insulin-like growth factor 1 (IGF-1)
IGF-1 receptor (IGF-1R)
epithelial-mesenchymal transition (EMT)
cancer
metastasis
PI3K/AKT pathway
RAS/MEK/ERK pathway
Online Access:http://www.mdpi.com/1422-0067/19/8/2411

Internet

http://www.mdpi.com/1422-0067/19/8/2411

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