Vitamin D deficiency exacerbates bleomycin-induced pulmonary fibrosis partially through aggravating TGF-β/Smad2/3-mediated epithelial-mesenchymal transition

Vitamin D deficiency exacerbates bleomycin-induced pulmonary fibrosis partially through aggravating TGF-β/Smad2/3-mediated epithelial-mesenchymal transition

Abstract Background Our earlier report indicated that active vitamin D3 inhibited epithelial-mesenchymal transition (EMT) in bleomycin (BLM)-induced pulmonary fibrosis. The objective of this study was to further investigate whether vitamin D deficiency exacerbates BLM-induced pulmonary fibrosis. Met...

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Bibliographic Details
Main Authors: Se-Ruo Li, Zhu-Xia Tan, Yuan-Hua Chen, Biao Hu, Cheng Zhang, Hua Wang, Hui Zhao, De-Xiang Xu
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Respiratory Research
Subjects:
Pulmonary fibrosis
Vitamin D deficiency
Epithelial-mesenchymal transition
Bleomycin
Mice
Online Access:http://link.springer.com/article/10.1186/s12931-019-1232-6

Internet

http://link.springer.com/article/10.1186/s12931-019-1232-6

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