Sphingosine kinase 1 expression enhances colon tumor growth

Sphingosine kinase 1 expression enhances colon tumor growth

Abstract Background Accumulating evidence suggests that sphingosine kinase 1 (SphK1)/sphingosine 1-phosphate pathway plays a pivotal role in colon carcinogenesis. Methods To further support the evidence, we investigated the effects of SphK1 using three separate animal models: SphK1 knockout mice, Sp...

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Bibliographic Details
Main Authors: Hideki Furuya, Yoshiko Shimizu, Paulette M. Tamashiro, Kayoko Iino, Jacek Bielawski, Owen T. M. Chan, Ian Pagano, Toshihiko Kawamori
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Journal of Translational Medicine
Subjects:
Sphingolipids
SphK1 KO mouse
Xenograft
SphK1 overexpression mouse
HT-29 cells
Online Access:http://link.springer.com/article/10.1186/s12967-017-1220-x

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http://link.springer.com/article/10.1186/s12967-017-1220-x

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