Arsenic trioxide reverses the chemoresistance in hepatocellular carcinoma: a targeted intervention of 14–3-3η/NF-κB feedback loop

Arsenic trioxide reverses the chemoresistance in hepatocellular carcinoma: a targeted intervention of 14–3-3η/NF-κB feedback loop

Abstract Background Multi-drug resistance (MDR) is one of the main obstacles for treatment of advanced/recurrent hepatocellular carcinoma (HCC). We have previously identified arsenic trioxide (ATO) as an effective metastasis/angiogenesis inhibitor in HCC. Here, we further found that MDR-HCC cells we...

Full description

Bibliographic Details
Main Authors: Yongxin Qiu, Yi Dai, Chi Zhang, Ye Yang, Ming Jin, Wenqi Shan, Jian Shen, Ming Lu, Zhaoyang Tang, Liang Ju, Yuting Wang, Ruonan Jiao, Yunwei Xia, Guangming Huang, Lihua Yang, Yuan Li, Jianping Zhang, Vincent Kam Wai Wong, Zhihong Jiang
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Hepatocellular carcinoma
Arsenic trioxide
Multi-drug resistance
14–3-3η
Nuclear factor kappa B
Online Access:http://link.springer.com/article/10.1186/s13046-018-1005-y

Internet

http://link.springer.com/article/10.1186/s13046-018-1005-y

Similar Items