Targeting MCL-1 sensitizes human esophageal squamous cell carcinoma cells to cisplatin-induced apoptosis

Targeting MCL-1 sensitizes human esophageal squamous cell carcinoma cells to cisplatin-induced apoptosis

Abstract Background Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies in China and is an exceptionally drug-resistant tumor with a 5-year survival rate less than 15%. Cisplatin is the most commonly used conventional chemotherapeutic drug for the treatment of ESCC, but...

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Bibliographic Details
Main Authors: Xinfang Yu, Wei Li, Zhenkun Xia, Li Xie, Xiaolong Ma, Qi Liang, Lijun Liu, Jian Wang, Xinmin Zhou, Yifeng Yang, Haidan Liu
Format: Article
Language:English
Published: BMC 2017-06-01
Series:BMC Cancer
Subjects:
Esophageal squamous cell carcinoma
Chemosensitization
MCL-1
Cisplatin
Apopotosis
Online Access:http://link.springer.com/article/10.1186/s12885-017-3442-y

Internet

http://link.springer.com/article/10.1186/s12885-017-3442-y

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