Effects of Mutations and Ligands on the Thermostability of the l-Arginine/Agmatine Antiporter AdiC and Deduced Insights into Ligand-Binding of Human l-Type Amino Acid Transporters

Effects of Mutations and Ligands on the Thermostability of the l-Arginine/Agmatine Antiporter AdiC and Deduced Insights into Ligand-Binding of Human l-Type Amino Acid Transporters

The l-arginine/agmatine transporter AdiC is a prokaryotic member of the SLC7 family, which enables pathogenic enterobacteria to survive the extremely acidic gastric environment. Wild-type AdiC from Escherichia coli, as well as its previously reported point mutants N22A and S26A, were overexpressed h...

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Bibliographic Details
Main Authors: Hüseyin Ilgü, Jean-Marc Jeckelmann, Claire Colas, Zöhre Ucurum, Avner Schlessinger, Dimitrios Fotiadis
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:International Journal of Molecular Sciences
Subjects:
acid resistance
AdiC
cancer metabolism
enterobacteria
">l-arginine/agmatine transporter
">l-type amino acid transporter
LAT1
melting temperature
thermostability
Online Access:http://www.mdpi.com/1422-0067/19/3/918

Internet

http://www.mdpi.com/1422-0067/19/3/918

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