Selective Loss of Brain-Derived Neurotrophic Factor Exacerbates Brain Injury by Enhancing Neuroinflammation in Experimental Streptococcus pneumoniae Meningitis

Selective Loss of Brain-Derived Neurotrophic Factor Exacerbates Brain Injury by Enhancing Neuroinflammation in Experimental Streptococcus pneumoniae Meningitis

Streptococcus pneumoniae meningitis is a life-threatening bacterial infection of the central nervous system (CNS), and its unfavorable prognosis usually results from an intense inflammatory response. Recent studies have shown that brain-derived neurotrophic factor (BDNF) mediates anti-inflammatory a...

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Bibliographic Details
Main Authors: Shengnan Zhao, Zhijie Zhang, Danfeng Xu, Yanfei Wang, Ling Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
Streptococcus pneumoniae meningitis
brain-derived neurotrophic factor
microglia/macrophage
neuroinflammation
brain injury
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01357/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01357/full

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