A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways

A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways

Glioblastoma (GBM) is classified as proneural (PN), neural, mesenchymal (MES) and classical GBM. Here the authors show that Wnt signalling, miR-125b and miR-20b establish a regulatory circuitry including FZD6 which distinguishes PN from the MES subtype.

Bibliographic Details
Main Authors: Tianzhi Huang, Angel A. Alvarez, Rajendra P. Pangeni, Craig M. Horbinski, Songjian Lu, Sung-Hak Kim, C. David James, Jeffery J. Raizer, John A. Kessler, Cameron W. Brenann, Erik P. Sulman, Gaetano Finocchiaro, Ming Tan, Ryo Nishikawa, Xinghua Lu, Ichiro Nakano, Bo Hu, Shi-Yuan Cheng
Format: Article
Language:English
Published: Nature Publishing Group 2016-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12885

Internet

https://doi.org/10.1038/ncomms12885

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