Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer

Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer

Chemotherapy resistance is a critical barrier in cancer treatment. Metabolic adaptations have been shown to fuel therapy resistance; however, little is known regarding the generality of these changes and whether specific therapies elicit unique metabolic alterations. Using a combination of metabolom...

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Bibliographic Details
Main Authors: Shawn McGuirk, Yannick Audet-Delage, Matthew G Annis, Yibo Xue, Mathieu Vernier, Kaiqiong Zhao, Catherine St-Louis, Lucía Minarrieta, David A Patten, Geneviève Morin, Celia MT Greenwood, Vincent Giguère, Sidong Huang, Peter M Siegel, Julie St-Pierre
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
breast cancer
anthracyclines
metabolomics
therapeutic resistance
bioenergetics
PGC-1
Online Access:https://elifesciences.org/articles/65150

Internet

https://elifesciences.org/articles/65150

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