Clonal tracing reveals diverse patterns of response to immune checkpoint blockade

Clonal tracing reveals diverse patterns of response to immune checkpoint blockade

Abstract Background Immune checkpoint blockade (ICB) therapy has improved patient survival in a variety of cancers, but only a minority of cancer patients respond. Multiple studies have sought to identify general biomarkers of ICB response, but elucidating the molecular and cellular drivers of resis...

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Main Authors: Shengqing Stan Gu, Xiaoqing Wang, Xihao Hu, Peng Jiang, Ziyi Li, Nicole Traugh, Xia Bu, Qin Tang, Chenfei Wang, Zexian Zeng, Jingxin Fu, Cliff Meyer, Yi Zhang, Paloma Cejas, Klothilda Lim, Jin Wang, Wubing Zhang, Collin Tokheim, Avinash Das Sahu, Xiaofang Xing, Benjamin Kroger, Zhangyi Ouyang, Henry Long, Gordon J. Freeman, Myles Brown, X. Shirley Liu
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Genome Biology
Subjects:
Clonal tracing
Immune checkpoint blockade
Heterogeneity
Tumor microenvironment
Mathematical modeling
Online Access:http://link.springer.com/article/10.1186/s13059-020-02166-1

Internet

http://link.springer.com/article/10.1186/s13059-020-02166-1

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