Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes

Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes

Abstract Background The growth factor receptor network (GFRN) plays a significant role in driving key oncogenic processes. However, assessment of global GFRN activity is challenging due to complex crosstalk among GFRN components, or pathways, and the inability to study complex signaling networks in...

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Bibliographic Details
Main Authors: Mumtahena Rahman, Shelley M. MacNeil, David F. Jenkins, Gajendra Shrestha, Sydney R. Wyatt, Jasmine A. McQuerry, Stephen R. Piccolo, Laura M. Heiser, Joe W. Gray, W. Evan Johnson, Andrea H. Bild
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Genome Medicine
Subjects:
Breast cancer
Gene expression signatures
Cancer phenotypes
Growth factor receptor network
Genomics
Targeted therapy
Online Access:http://link.springer.com/article/10.1186/s13073-017-0429-x

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http://link.springer.com/article/10.1186/s13073-017-0429-x

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