Mammalian histones facilitate antimicrobial synergy by disrupting the bacterial proton gradient and chromosome organization
Histones have a role in antimicrobial defense. Here, the authors show that the histone H2A and the antimicrobial peptide LL-37 exert synergistic effects by enhancing bacterial membrane pores and enabling H2A entry into the bacterial cytoplasm, where it reorganizes DNA and inhibits transcription.
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-08-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-17699-z |