Hyperforin inhibits Akt1 kinase activity and promotes caspase-mediated apoptosis involving Bad and Noxa activation in human myeloid tumor cells.

Hyperforin inhibits Akt1 kinase activity and promotes caspase-mediated apoptosis involving Bad and Noxa activation in human myeloid tumor cells.

BACKGROUND: The natural phloroglucinol hyperforin HF displays anti-inflammatory and anti-tumoral properties of potential pharmacological interest. Acute myeloid leukemia (AML) cells abnormally proliferate and escape apoptosis. Herein, the effects and mechanisms of purified HF on AML cell dysfunction...

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Bibliographic Details
Main Authors: Faten Merhi, Ruoping Tang, Marion Piedfer, Julie Mathieu, Isabelle Bombarda, Murhaf Zaher, Jean-Pierre Kolb, Christian Billard, Brigitte Bauvois
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3188562?pdf=render

Internet

http://europepmc.org/articles/PMC3188562?pdf=render

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