Acute Detubulation of Ventricular Myocytes Amplifies the Inhibitory Effect of Cholinergic Agonist on Intracellular Ca2+ Transients

Acute Detubulation of Ventricular Myocytes Amplifies the Inhibitory Effect of Cholinergic Agonist on Intracellular Ca2+ Transients

Muscarinic receptors expressed in cardiac myocytes play a critical role in the regulation of heart function by the parasympathetic nervous system. How the structural organization of cardiac myocytes affects the regulation of Ca2+ handling by muscarinic receptors is not well-defined. Using confocal C...

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Bibliographic Details
Main Authors: Andriy E. Belevych, Vladimir Bogdanov, Dmitry A. Terentyev, Sandor Gyorke
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Physiology
Subjects:
excitation-contraction coupling
t-tubule
muscarinic receptor agonist
calcium microdomains
ventricular myocyte
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.725798/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.725798/full

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