Valproic acid induces microglial dysfunction, not apoptosis, in human glial cultures

Valproic acid induces microglial dysfunction, not apoptosis, in human glial cultures

Valproic acid (VPA) is widely used for the treatment of mood disorders and epilepsy, but its mechanism of action is unclear. In vivo and in vitro studies using rodent models have demonstrated that VPA has both neuroprotective and neurotrophic effects. These beneficial effects are, in part, through m...

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Bibliographic Details
Main Authors: Hannah M. Gibbons, Amy M. Smith, H. Heng Teoh, Peter M. Bergin, Edward W. Mee, Richard L.M. Faull, Mike Dragunow
Format: Article
Language:English
Published: Elsevier 2011-01-01
Series:Neurobiology of Disease
Subjects:
Microglia
Valproic acid
Epilepsy
Apoptosis
Phagocytosis
Primary adult human cell culture
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110002962

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http://www.sciencedirect.com/science/article/pii/S0969996110002962

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