A Proposed Concept for Defective Mitophagy Leading to Late Stage Ineffective Erythropoiesis in Pyruvate Kinase Deficiency

A Proposed Concept for Defective Mitophagy Leading to Late Stage Ineffective Erythropoiesis in Pyruvate Kinase Deficiency

Pyruvate kinase deficiency (PKD) is a rare congenital hemolytic anemia caused by mutations in the PKLR gene. Here, we review pathophysiological aspects of PKD, focusing on the interplay between pyruvate kinase (PK)-activity and reticulocyte maturation in the light of ferroptosis, an iron-dependent p...

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Bibliographic Details
Main Authors: Annelies Johanna van Vuren, Eduard Johannes van Beers, Richard van Wijk
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Physiology
Subjects:
reticulocytes
pyruvate kinase deficiency
ferroptosis
mitophagy
GPX4
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.609103/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.609103/full

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