Evidence for Multiple Origins of De Novo Formed Vascular Smooth Muscle Cells in Pulmonary Hypertension: Challenging the Dominant Model of Pre-Existing Smooth Muscle Expansion

Evidence for Multiple Origins of De Novo Formed Vascular Smooth Muscle Cells in Pulmonary Hypertension: Challenging the Dominant Model of Pre-Existing Smooth Muscle Expansion

Vascular remodeling is a prominent feature of pulmonary hypertension. This process involves increased muscularization of already muscularized vessels as well as neo-muscularization of non-muscularized vessels. The cell-of-origin of the newly formed vascular smooth muscle cells has been a subject of...

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Bibliographic Details
Main Authors: Xuran Chu, Negah Ahmadvand, Jin-San Zhang, Werner Seeger, Saverio Bellusci, Elie El Agha
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Environmental Research and Public Health
Subjects:
vascular remodeling
pulmonary hypertension
vascular smooth muscle cells
Online Access:https://www.mdpi.com/1660-4601/18/16/8584

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https://www.mdpi.com/1660-4601/18/16/8584

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