Evidence for Multiple Origins of De Novo Formed Vascular Smooth Muscle Cells in Pulmonary Hypertension: Challenging the Dominant Model of Pre-Existing Smooth Muscle Expansion
Vascular remodeling is a prominent feature of pulmonary hypertension. This process involves increased muscularization of already muscularized vessels as well as neo-muscularization of non-muscularized vessels. The cell-of-origin of the newly formed vascular smooth muscle cells has been a subject of...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-08-01
|
Series: | International Journal of Environmental Research and Public Health |
Subjects: | |
Online Access: | https://www.mdpi.com/1660-4601/18/16/8584 |
id |
doaj-b344d5a0688b4f2f898006aeebe70030 |
---|---|
record_format |
Article |
spelling |
doaj-b344d5a0688b4f2f898006aeebe700302021-08-26T13:49:35ZengMDPI AGInternational Journal of Environmental Research and Public Health1661-78271660-46012021-08-01188584858410.3390/ijerph18168584Evidence for Multiple Origins of De Novo Formed Vascular Smooth Muscle Cells in Pulmonary Hypertension: Challenging the Dominant Model of Pre-Existing Smooth Muscle ExpansionXuran Chu0Negah Ahmadvand1Jin-San Zhang2Werner Seeger3Saverio Bellusci4Elie El Agha5Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL), 35392 Giessen, GermanyDepartment of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL), 35392 Giessen, GermanySchool of Pharmacy, Wenzhou Medical University, Wenzhou 325015, ChinaDepartment of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL), 35392 Giessen, GermanyDepartment of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL), 35392 Giessen, GermanyDepartment of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL), 35392 Giessen, GermanyVascular remodeling is a prominent feature of pulmonary hypertension. This process involves increased muscularization of already muscularized vessels as well as neo-muscularization of non-muscularized vessels. The cell-of-origin of the newly formed vascular smooth muscle cells has been a subject of intense debate in recent years. Identifying these cells may have important clinical implications since it opens the door for attempts to therapeutically target the progenitor cells and/or reverse the differentiation of their progeny. In this context, the dominant model is that these cells derive from pre-existing smooth muscle cells that are activated in response to injury. In this mini review, we present the evidence that is in favor of this model and, at the same time, highlight other studies indicating that there are alternative cellular sources of vascular smooth muscle cells in pulmonary vascular remodeling.https://www.mdpi.com/1660-4601/18/16/8584vascular remodelingpulmonary hypertensionvascular smooth muscle cells |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xuran Chu Negah Ahmadvand Jin-San Zhang Werner Seeger Saverio Bellusci Elie El Agha |
spellingShingle |
Xuran Chu Negah Ahmadvand Jin-San Zhang Werner Seeger Saverio Bellusci Elie El Agha Evidence for Multiple Origins of De Novo Formed Vascular Smooth Muscle Cells in Pulmonary Hypertension: Challenging the Dominant Model of Pre-Existing Smooth Muscle Expansion International Journal of Environmental Research and Public Health vascular remodeling pulmonary hypertension vascular smooth muscle cells |
author_facet |
Xuran Chu Negah Ahmadvand Jin-San Zhang Werner Seeger Saverio Bellusci Elie El Agha |
author_sort |
Xuran Chu |
title |
Evidence for Multiple Origins of De Novo Formed Vascular Smooth Muscle Cells in Pulmonary Hypertension: Challenging the Dominant Model of Pre-Existing Smooth Muscle Expansion |
title_short |
Evidence for Multiple Origins of De Novo Formed Vascular Smooth Muscle Cells in Pulmonary Hypertension: Challenging the Dominant Model of Pre-Existing Smooth Muscle Expansion |
title_full |
Evidence for Multiple Origins of De Novo Formed Vascular Smooth Muscle Cells in Pulmonary Hypertension: Challenging the Dominant Model of Pre-Existing Smooth Muscle Expansion |
title_fullStr |
Evidence for Multiple Origins of De Novo Formed Vascular Smooth Muscle Cells in Pulmonary Hypertension: Challenging the Dominant Model of Pre-Existing Smooth Muscle Expansion |
title_full_unstemmed |
Evidence for Multiple Origins of De Novo Formed Vascular Smooth Muscle Cells in Pulmonary Hypertension: Challenging the Dominant Model of Pre-Existing Smooth Muscle Expansion |
title_sort |
evidence for multiple origins of de novo formed vascular smooth muscle cells in pulmonary hypertension: challenging the dominant model of pre-existing smooth muscle expansion |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1661-7827 1660-4601 |
publishDate |
2021-08-01 |
description |
Vascular remodeling is a prominent feature of pulmonary hypertension. This process involves increased muscularization of already muscularized vessels as well as neo-muscularization of non-muscularized vessels. The cell-of-origin of the newly formed vascular smooth muscle cells has been a subject of intense debate in recent years. Identifying these cells may have important clinical implications since it opens the door for attempts to therapeutically target the progenitor cells and/or reverse the differentiation of their progeny. In this context, the dominant model is that these cells derive from pre-existing smooth muscle cells that are activated in response to injury. In this mini review, we present the evidence that is in favor of this model and, at the same time, highlight other studies indicating that there are alternative cellular sources of vascular smooth muscle cells in pulmonary vascular remodeling. |
topic |
vascular remodeling pulmonary hypertension vascular smooth muscle cells |
url |
https://www.mdpi.com/1660-4601/18/16/8584 |
work_keys_str_mv |
AT xuranchu evidenceformultipleoriginsofdenovoformedvascularsmoothmusclecellsinpulmonaryhypertensionchallengingthedominantmodelofpreexistingsmoothmuscleexpansion AT negahahmadvand evidenceformultipleoriginsofdenovoformedvascularsmoothmusclecellsinpulmonaryhypertensionchallengingthedominantmodelofpreexistingsmoothmuscleexpansion AT jinsanzhang evidenceformultipleoriginsofdenovoformedvascularsmoothmusclecellsinpulmonaryhypertensionchallengingthedominantmodelofpreexistingsmoothmuscleexpansion AT wernerseeger evidenceformultipleoriginsofdenovoformedvascularsmoothmusclecellsinpulmonaryhypertensionchallengingthedominantmodelofpreexistingsmoothmuscleexpansion AT saveriobellusci evidenceformultipleoriginsofdenovoformedvascularsmoothmusclecellsinpulmonaryhypertensionchallengingthedominantmodelofpreexistingsmoothmuscleexpansion AT elieelagha evidenceformultipleoriginsofdenovoformedvascularsmoothmusclecellsinpulmonaryhypertensionchallengingthedominantmodelofpreexistingsmoothmuscleexpansion |
_version_ |
1721192963526098944 |