High Seeding Density Induces Local Hypoxia and Triggers a Proinflammatory Response in Isolated Human Islets

Hypoxia is the main threat to morphological and functional integrity of isolated pancreatic islets. Lack of oxygen seems to be of particular importance for functionality of encapsulated islets. The present study was initiated as an experimental model for the environment experienced by human islets i...

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Bibliographic Details
Main Authors: Daniel Brandhorst, Heide Brandhorst, Niamh Mullooly, Samuel Acreman, Paul R. V. Johnson
Format: Article
Language:English
Published: SAGE Publishing 2016-08-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368915X689929