Statins increase hepatic cholesterol synthesis and stimulate fecal cholesterol elimination in mice

Statins increase hepatic cholesterol synthesis and stimulate fecal cholesterol elimination in mice

Statins are competitive inhibitors of HMG-CoA reductase, the rate-limiting enzyme of cholesterol synthesis. Statins reduce plasma cholesterol levels, but whether this is actually caused by inhibition of de novo cholesterol synthesis has not been clearly established. Using three different statins, we...

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Bibliographic Details
Main Authors: Marleen Schonewille, Jan Freark de Boer, Laura Mele, Henk Wolters, Vincent W. Bloks, Justina C. Wolters, Jan A. Kuivenhoven, Uwe J.F. Tietge, Gemma Brufau, Albert K. Groen
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Journal of Lipid Research
Subjects:
cholesterol/absorption
cholesterol/biosynthesis
liver
intestine
biliary cholesterol
transintestinal cholesterol excretion
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520352172

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http://www.sciencedirect.com/science/article/pii/S0022227520352172

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