Statins increase hepatic cholesterol synthesis and stimulate fecal cholesterol elimination in mice
Statins are competitive inhibitors of HMG-CoA reductase, the rate-limiting enzyme of cholesterol synthesis. Statins reduce plasma cholesterol levels, but whether this is actually caused by inhibition of de novo cholesterol synthesis has not been clearly established. Using three different statins, we...
Main Authors: | Marleen Schonewille, Jan Freark de Boer, Laura Mele, Henk Wolters, Vincent W. Bloks, Justina C. Wolters, Jan A. Kuivenhoven, Uwe J.F. Tietge, Gemma Brufau, Albert K. Groen |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2016-08-01
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Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520352172 |
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