Increased Expression of Micro-RNA-23a Mediates Chemoresistance to Cytarabine in Acute Myeloid Leukemia

Increased Expression of Micro-RNA-23a Mediates Chemoresistance to Cytarabine in Acute Myeloid Leukemia

Resistance to chemotherapy is one of the primary obstacles in acute myeloid leukemia (AML) therapy. Micro-RNA-23a (miR-23a) is frequently deregulated in AML and has been linked to chemoresistance in solid cancers. We, therefore, studied its role in chemoresistance to cytarabine (AraC), which forms t...

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Bibliographic Details
Main Authors: Stefan Hatzl, Bianca Perfler, Sonja Wurm, Barbara Uhl, Franz Quehenberger, Susanne Ebner, Jakob Troppmair, Andreas Reinisch, Albert Wölfler, Heinz Sill, Armin Zebisch
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
micro-rna-23a
acute myeloid leukemia
therapeutic resistance
cytarabine
Online Access:https://www.mdpi.com/2072-6694/12/2/496

Internet

https://www.mdpi.com/2072-6694/12/2/496

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