Heterogeneity of TP53 Mutations and P53 Protein Residual Function in Cancer: Does It Matter?

Heterogeneity of TP53 Mutations and P53 Protein Residual Function in Cancer: Does It Matter?

The human TP53 locus, located on the short arm of chromosome 17, encodes a tumour suppressor protein which functions as a tetrameric transcription factor capable of regulating the expression of a plethora of target genes involved in cell cycle arrest, apoptosis, DNA repair, autophagy, and metabolism...

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Bibliographic Details
Main Authors: Paola Monti, Paola Menichini, Andrea Speciale, Giovanna Cutrona, Franco Fais, Elisa Taiana, Antonino Neri, Riccardo Bomben, Massimo Gentile, Valter Gattei, Manlio Ferrarini, Fortunato Morabito, Gilberto Fronza
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Oncology
Subjects:
TP53 mutations
chronic lymphocytic leukemia
clinical impact
P53 protein function
reactivation of P53
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.593383/full

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https://www.frontiersin.org/articles/10.3389/fonc.2020.593383/full

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