TMAO Aggregates Neurological Damage Following Ischemic Stroke by Promoting Reactive Astrocytosis and Glial Scar Formation via the Smurf2/ALK5 Axis

TMAO Aggregates Neurological Damage Following Ischemic Stroke by Promoting Reactive Astrocytosis and Glial Scar Formation via the Smurf2/ALK5 Axis

Ischemic stroke has been reported to cause significant changes to memory, thinking, and behavior. Intriguingly, recently reported studies have indicated the association of Trimethylamine N-oxide (TMAO) with the acute phase of ischemic stroke. However, the comprehensive underlying mechanism remained...

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Bibliographic Details
Main Authors: Haibo Su, Shaoping Fan, Lingqiong Zhang, Hui Qi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
ischemic stroke
trimethylamine N-oxide
SMAD specific E3 ubiquitin-protein ligase 2
activin receptor-like kinase-5
glial scarring
neurological function
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.569424/full

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https://www.frontiersin.org/articles/10.3389/fncel.2021.569424/full

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