N-acetyl-l-tryptophan delays disease onset and extends survival in an amyotrophic lateral sclerosis transgenic mouse model

N-acetyl-l-tryptophan delays disease onset and extends survival in an amyotrophic lateral sclerosis transgenic mouse model

Background: Whether l-NAT, a cytochrome c release inhibitor and an antagonist of NK-1R, provides protection in ALS is not known. Results: l-NAT delays disease onset and mortality in mSOD1G93A ALS mice by inhibiting mitochondrial cell death pathways, inflammation, and NK-1R downregulation. Conclusion...

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Bibliographic Details
Main Authors: Wei Li, Anastasios Fotinos, Qiaofeng Wu, Yanchun Chen, Yongjin Zhu, Sergei Baranov, Yanyang Tu, Edward W. Zhou, Bharati Sinha, Bruce S. Kristal, Xin Wang
Format: Article
Language:English
Published: Elsevier 2015-08-01
Series:Neurobiology of Disease
Subjects:
N-acetyl-l-tryptophan
Amyotrophic lateral sclerosis
mSOD1G93A mice
Neuroprotection
Mitochondrial death pathway
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115001643

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http://www.sciencedirect.com/science/article/pii/S0969996115001643

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