Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System

Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System

Endophilin-A, a well-characterized endocytic adaptor essential for synaptic vesicle recycling, has recently been linked to neurodegeneration. We report here that endophilin-A deficiency results in impaired movement, age-dependent ataxia, and neurodegeneration in mice. Transcriptional analysis of end...

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Bibliographic Details
Main Authors: John D. Murdoch, Christine M. Rostosky, Sindhuja Gowrisankaran, Amandeep S. Arora, Sandra-Fausia Soukup, Ramon Vidal, Vincenzo Capece, Siona Freytag, Andre Fischer, Patrik Verstreken, Stefan Bonn, Nuno Raimundo, Ira Milosevic
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
endophilin
FBXO32
endocytosis
autophagy
ubiquitin-proteasome system
neurodegeneration
ataxia
Parkinson’s disease
next-generation sequencing
protein homeostasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716313146

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http://www.sciencedirect.com/science/article/pii/S2211124716313146

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