Investigating the inhibitory effect of miR-34a, miR-449a, miR-1827, and miR-106b on target genes including NOTCH1, c-Myc, and CCND1 in human T cell acute lymphoblastic leukemia clinical samples and cell line

Investigating the inhibitory effect of miR-34a, miR-449a, miR-1827, and miR-106b on target genes including NOTCH1, c-Myc, and CCND1 in human T cell acute lymphoblastic leukemia clinical samples and cell line

<em><strong>Objective(s):</strong></em> microRNAs are small non-coding molecules that regulate gene expression in various biological processes. T-cell acute lymphoblastic leukemia (T-ALL) is a malignancy accompanied with genetic aberrations and accounts for 20% of children’s...

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Bibliographic Details
Main Authors: Tohid Naderi, Samira Mohammadi Yeganeh, Neda Mohammadi-Hezaveh, Razie Hadavi, Ahmad Gharehbaghian, Nader Vazifeh Shiran, Vahid Fallah Azad, Mahdi Paryan
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2020-03-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
bioinformatics
biomarker
mirna
notch signaling pathway
t-cell acute lymphoblastic leukemia
Online Access:http://ijbms.mums.ac.ir/article_14413_d2955d29af2305e90a79e3902646446f.pdf

Internet

http://ijbms.mums.ac.ir/article_14413_d2955d29af2305e90a79e3902646446f.pdf

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