The Contribution of Gi/o Protein to Opioid Antinociception in an Oxaliplatin-Induced Neuropathy Rat Model

The Contribution of Gi/o Protein to Opioid Antinociception in an Oxaliplatin-Induced Neuropathy Rat Model

Abstract.: Oxaliplatin is a chemotherapeutic agent that induces chronic refractory neuropathy. To determine whether opioids effectively relieve this chronic neuropathy, we investigated the efficacies of morphine, oxycodone, and fentanyl, and the mechanisms underlying opioid antinociception, in oxali...

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Bibliographic Details
Main Authors: Tomoe Kanbara, Atsushi Nakamura, Keiko Takasu, Koichi Ogawa, Masahiro Shibasaki, Tomohisa Mori, Tsutomu Suzuki, Minoru Hasegawa, Gaku Sakaguchi, Toshiyuki Kanemasa
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319300805

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http://www.sciencedirect.com/science/article/pii/S1347861319300805

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