Mild and selective reduction of aldehydes utilising sodium dithionite under flow conditions

We recently reported a novel hybrid batch–flow synthesis of the antipsychotic drug clozapine in which the reduction of a nitroaryl group is described under flow conditions using sodium dithionite. We now report the expansion of this method to include the reduction of aldehydes. The method developed...

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Bibliographic Details
Main Authors: Nicole C. Neyt, Darren L. Riley
Format: Article
Language:English
Published: Beilstein-Institut 2018-06-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Online Access:https://doi.org/10.3762/bjoc.14.129