Urea Cycle Related Amino Acids Measured in Dried Bloodspots Enable Long-Term In Vivo Monitoring and Therapeutic Adjustment

Urea Cycle Related Amino Acids Measured in Dried Bloodspots Enable Long-Term In Vivo Monitoring and Therapeutic Adjustment

Background: Dried bloodspots are easy to collect and to transport to assess various metabolites, such as amino acids. Dried bloodspots are routinely used for diagnosis and monitoring of some inherited metabolic diseases. Methods: Measurement of amino acids from dried blood spots by liquid chromatogr...

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Bibliographic Details
Main Authors: Julien Baruteau, Youssef Khalil, Stephanie Grunewald, Marta Zancolli, Anupam Chakrapani, Maureen Cleary, James Davison, Emma Footitt, Simon N. Waddington, Paul Gissen, Philippa Mills
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Metabolites
Subjects:
tandem mass spectrometry
dried blood spots
urea cycle
amino acids
argininosuccinate lyase
Online Access:https://www.mdpi.com/2218-1989/9/11/275

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https://www.mdpi.com/2218-1989/9/11/275

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