Evaluating power and type 1 error in large pedigree analyses of binary traits.

Evaluating power and type 1 error in large pedigree analyses of binary traits.

Studying population isolates with large, complex pedigrees has many advantages for discovering genetic susceptibility loci; however, statistical analyses can be computationally challenging. Allelic association tests need to be corrected for relatedness among study participants, and linkage analyses...

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Bibliographic Details
Main Authors: Anna C Cummings, Eric Torstenson, Mary F Davis, Laura N D'Aoust, William K Scott, Margaret A Pericak-Vance, William S Bush, Jonathan L Haines
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3643945?pdf=render

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http://europepmc.org/articles/PMC3643945?pdf=render

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