The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy

The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy

Previous studies have shown that prolyl oligopeptidase (PREP) negatively regulates autophagy and increases the aggregation of alpha-synuclein (αSyn), linking it to the pathophysiology of Parkinson’s disease. Our earlier results have revealed that the potent small molecular PREP inhibitor KYP-2047 is...

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Bibliographic Details
Main Authors: Tommi P. Kilpeläinen, Laura Hellinen, Johannes Vrijdag, Xu Yan, Reinis Svarcbahs, Kati-Sisko Vellonen, Anne-Marie Lambeir, Henri Huttunen, Arto Urtti, Erik A.A Wallen, Timo T. Myöhänen
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Serine protease
Alpha-Synuclein
Autophagy
Parkinson’s disease
Protein conformation
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220304455

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http://www.sciencedirect.com/science/article/pii/S0753332220304455

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