Single-Molecule Super-Resolution Microscopy Reveals Heteromeric Complexes of MET and EGFR upon Ligand Activation

Single-Molecule Super-Resolution Microscopy Reveals Heteromeric Complexes of MET and EGFR upon Ligand Activation

Receptor tyrosine kinases (RTKs) orchestrate cell motility and differentiation. Deregulated RTKs may promote cancer and are prime targets for specific inhibitors. Increasing evidence indicates that resistance to inhibitor treatment involves receptor cross-interactions circumventing inhibition of one...

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Bibliographic Details
Main Authors: Marie-Lena I.E. Harwardt, Mark S. Schröder, Yunqing Li, Sebastian Malkusch, Petra Freund, Shashi Gupta, Nebojsa Janjic, Sebastian Strauss, Ralf Jungmann, Marina S. Dietz, Mike Heilemann
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
receptor tyrosine kinases
MET
EGFR
receptor cross-interaction
single-molecule localization microscopy
single-particle tracking
Online Access:https://www.mdpi.com/1422-0067/21/8/2803

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https://www.mdpi.com/1422-0067/21/8/2803

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